Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-ROCK1 Antibody Picoband®

Boster Bio Anti-ROCK1 Antibody Picoband® catalog # A00722-5. Tested in ELISA, ICC/IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.

Synonyms

Ornithine carbamoyltransferase, mitochondrial;2.1.3.3; Ornithine transcarbamylase; OTCase; OTC

Gene Name

ROCK1

Gene ID

6093

UniProt

Q13464

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ROCK1 recombinant protein (Position: K601-N1319) .

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in liver and intestinal mucosa.

Applications

WB, IHC, ICC/IF, ELISA

Field of Research

Biochemicals, Chemical Type, Neuroscience, Neurotransmission, Obesity, Receptors / Channels

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

References & Citations

1. Anderson, S. C., SundarRaj, N. Regulation of a Rho-associated kinase expression during the corneal epithelial cell cycle. Invest. Ophthal. Vis. Sci. 42: 933-940, 2001. 2. Bito, H., Furuyashiki, T., Ishihara, H., Shibasaki, Y., Ohashi, K., Mizuno, K., Maekawa, M., Ishizaki, T., Narumiya, S. A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron 26: 431-441, 2000. 3. Bivalacqua, T. J., Champion, H. C., Usta, M. F., Cellek, S., Chitaley, K., Webb, R. C., Lewis, R. L., Mills, T. M., Hellstrom, W. J. G., Kadowitz, P. J. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proc. Nat. Acad. Sci. 101: 9121-9126, 2004.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00722-5

Product MSDS

https://www.bosterbio.com/msds?sku=A00722-5

Calculated Molecular Weight

158 kDa

Observed Molecular Weight

158 kDa

Gene Name Synonym

Ornithine carbamoyltransferase, mitochondrial

Subcellular Location

Mitochondrion matrix.

Protein Name

Ornithine carbamoyltransferase, mitochondrial

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

GDI2 Polyclonal Antibody
bs-55083R 100 µL

GDI2 Polyclonal Antibody

Ask
View Details
Recombinant Human HLA F Protein
NBP2-51744-0.02mg 0.02 mg

Recombinant Human HLA F Protein

Ask
View Details
Anti-GRK2/GRK2 Antibody Picoband® (APC Conjugate)
A01473-1-APC 100 µg/Vial

Anti-GRK2/GRK2 Antibody Picoband® (APC Conjugate)

Ask
View Details
Rabbit Anti-Human IgG (H+L) Absorbed against mouse immunoglobulins
GWB-366780 1 mg

Rabbit Anti-Human IgG (H+L) Absorbed against mouse immunoglobulins

Ask
View Details