Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-ROCK1 Antibody Picoband®

Boster Bio Anti-ROCK1 Antibody Picoband® catalog # A00722-5. Tested in ELISA, ICC/IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.

Synonyms

Ornithine carbamoyltransferase, mitochondrial;2.1.3.3; Ornithine transcarbamylase; OTCase; OTC

Gene Name

ROCK1

Gene ID

6093

UniProt

Q13464

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ROCK1 recombinant protein (Position: K601-N1319) .

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in liver and intestinal mucosa.

Applications

WB, IHC, ICC/IF, ELISA

Field of Research

Biochemicals, Chemical Type, Neuroscience, Neurotransmission, Obesity, Receptors / Channels

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

References & Citations

1. Anderson, S. C., SundarRaj, N. Regulation of a Rho-associated kinase expression during the corneal epithelial cell cycle. Invest. Ophthal. Vis. Sci. 42: 933-940, 2001. 2. Bito, H., Furuyashiki, T., Ishihara, H., Shibasaki, Y., Ohashi, K., Mizuno, K., Maekawa, M., Ishizaki, T., Narumiya, S. A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron 26: 431-441, 2000. 3. Bivalacqua, T. J., Champion, H. C., Usta, M. F., Cellek, S., Chitaley, K., Webb, R. C., Lewis, R. L., Mills, T. M., Hellstrom, W. J. G., Kadowitz, P. J. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proc. Nat. Acad. Sci. 101: 9121-9126, 2004.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

158 kDa

Observed Molecular Weight

158 kDa

Gene Name Synonym

Ornithine carbamoyltransferase, mitochondrial

Subcellular Location

Mitochondrion matrix.

Protein Name

Ornithine carbamoyltransferase, mitochondrial

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Human DUS1L (NM_022156) AAV Particle
RC209015A1V 250 µL

Human DUS1L (NM_022156) AAV Particle

Ask
View Details
FAM102A (NM_203305) Human Tagged ORF Clone
RG220739 10 µg

FAM102A (NM_203305) Human Tagged ORF Clone

Ask
View Details
TRNAK28 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
48124111 3x 1.0 µg

TRNAK28 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

Ask
View Details
Mouse Monoclonal ZIM2 Antibody (OTI6D12) [Alexa Fluor 647]
NBP2-74928AF647 0.1 mL

Mouse Monoclonal ZIM2 Antibody (OTI6D12) [Alexa Fluor 647]

Ask
View Details
HYPE (FICD) Rabbit Polyclonal Antibody
TA341881 100 µL

HYPE (FICD) Rabbit Polyclonal Antibody

Ask
View Details