Anti-OMP Antibody Picoband® Fluoro594 Conjugated

Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade.

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and ly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The ionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

1. Buiakova, O. I., Baker, H., Scott, J. W., Farbman, A., Kream, R., Grillo, M., Franzen, L., Richman, M., Davis, L. M., Abbondanzo, S., Stewart, C. L., Margolis, F. L. Olfactory marker protein (OMP) gene deletion cause altered physiological activity of olfactory sensory neurons. Proc. Nat. Acad. Sci. 93: 9858-9863, 1996. 2. Evans, K. L., Fantes, J., Simpson, C., Arveiler, B., Muir, W., Fletcher, J., van Heyningen, V., Steel, K. P., Brown, K. A., Brown, S. D. M., St. Clair, D., Porteous, D. J. Human olfactory markerprotein maps close to tyrosinase and is a candidate gene for Usher syndrome type I. Hum. Molec. Genet. 2: 115-118, 1993. 3. Rogers, K. E., Dasgupta, P., Gubler, U., Grillo, M., Khew-Goodall, Y. S., Margolis, F. L.Molecular cloning and sequencing of a cDNA for olfactory marker protein. Proc. Nat. Acad. Sci. 84: 1704-1708, 1987.