Anti-RIMBP2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
RIMS binding protein 2 is a protein that in humans is encoded by the RIMBP2 gene. Predicted to be involved in neuromuscular synaptic transmission. Predicted to be located in plasma membrane and synapse. Predicted to be active in presynaptic active zone cytoplasmic component.
Synonyms
Transmembrane protein 240; TMEM240; C1orf70
Gene Name
RIMBP2
Gene ID
23504
UniProt
O15034
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human RIMBP2 recombinant protein (Position: K351-H1049) .
Clonality
Polyclonal
Tissue Specificity
Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Applications
Flow Cytometry
Field of Research
Cell Biology
Purification
Immunogen affinity purified.
Form
Liquid
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
References & Citations
1. Mittelstaedt, T., Schoch, S. Structure and evolution of RIM-BP genes: identification of a novel family member. Gene 403: 70-79, 2007. 2. Nagase, T., Ishikawa, K., Nakajima, D., Ohira, M., Seki, N., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 4: 141-150, 1997. 3. Wang, Y., Sugita, S., Sudhof, T. C. The RIM/NIM family of neuronal C2 domain proteins: interactions with Rab3 and a new class of Src homology 3 domain proteins. J. Biol. Chem. 275: 20033-20044, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
19908 MW
Applications Notes
6
Gene Name Synonym
Transmembrane protein 240
Subcellular Location
Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .
Protein Name
Transmembrane protein 240
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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