Anti-C20orf74/RALGAPA2 Antibody Picoband® Fluoro594 Conjugated
Selected Variant
A10416-1-Fluoro594
Size: 100 µg/Vial
Product Specifications
Background
Predicted to enable GTPase activator activity and protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. Located in cytosol and plasma membrane.
Synonyms
E3 ubiquitin-protein ligase RNF169; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169; RNF169; KIAA1991
Gene Name
RALGAPA2
Gene ID
57186
UniProt
Q2PPJ7
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human C20orf74/RALGAPA2 recombinant protein (Position: R246-Q1556) .
Clonality
Polyclonal
Tissue Specificity
Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.
Applications
Flow Cytometry
Field of Research
Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage
Purification
Immunogen affinity purified.
Form
Liquid
Function
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
References & Citations
1. Gridley, S., Chavez, J. A., Lane, W. S., Lienhard, G. E. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. Cell. Signal. 18: 1626-1632, 2006. 2. Gross, M. B. Personal Communication. Baltimore, Md. 4/6/2020. 3. Saito, R., Shirakawa, R., Nishiyama, H., Kobayashi, T., Kawato, M., Kanno, T., Nishizawa, K., Matsui, Y., Ohbayashi, T., Horiguchi, M., Nakamura, T., Ikeda, T., Yamane, K., Nakayama, E., Nakamura, E., Toda, Y., Kimura, T., Kita, T., Ogawa, O., Horiuchi, H. Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene 32: 894-902, 2013.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
41409 MW
Applications Notes
6
Gene Name Synonym
Ring finger protein 169
Subcellular Location
Nucleoplasm.
Protein Name
Protein NDRG3
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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