Anti-RRP1B Antibody Picoband® Fluoro488 Conjugated

RRP1B (ribosomal RNA processing 1 homolog B), also known as KIAA0179, is a human gene which is located on Chromosome 21. Enables transcription coactivator activity. Involved in several processes, including cellular response to virus; positive regulation by host of viral transcription; and positive regulation of transcription by RNA polymerase II. Located in chromosome; granular component; and nucleoplasm.

Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.

1. Chamousset, D., De Wever, V., Moorhead, G. B., Chen, Y., Boisvert, F.-M., Lamond, A. I., Trinkle-Mulcahy, L. RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits. Molec. Biol. Cell 21: 4212-4226, 2010. 2. Jansen, E., Meulemans, S. M. P., Orlans, I. C. R., Van de Ven, W. J. M. The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3. Genomics 42: 336-341, 1997. 3. Nagase, T., Seki, N., Ishikawa, K., Tanaka, A., Nomura, N. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 3: 17-24, 1996.