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Anti-RNGTT Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

MRNA-capping enzyme is a protein that in humans is encoded by the RNGTT gene. Enables mRNA guanylyltransferase activity and triphosphatase activity. Involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm.

Synonyms

B-cell differentiation antigen CD72; Lyb-2; CD72; CD72

Gene Name

RNGTT

Gene ID

8732

UniProt

O60942

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RNGTT recombinant protein (Position: L11-D438) .

Clonality

Polyclonal

Tissue Specificity

Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Plays a role in B-cell proliferation and differentiation.

References & Citations

1. Pillutla, R. C., Shimamoto, A., Furuichi, Y., Shatkin, A. J. Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively. Genomics 54: 351-353, 1998. 2. Tsukamoto, T., Shibagaki, Y., Murakoshi, T., Suzuki, M., Nakamura, A., Gotoh, H., Mizumoto, K. Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. Biochem. Biophys. Res. Commun. 243: 101-108, 1998. 3. Yamada-Okabe, T., Doi, R., Shimmi, O., Arisawa, M., Yamada-Okabe, H. Isolation and characterization of a human cDNA for mRNA 5-prime-capping enzyme. Nucleic Acids Res. 26: 1700-1706, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

CD72 molecule

Subcellular Location

Membrane; Single-pass type II membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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