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Anti-RNF212 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.

Synonyms

Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166; EVA1A; FAM176A; TMEM166; SP24

Gene Name

RNF212

Gene ID

285498

UniProt

Q495C1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RNF212 recombinant protein (Position: Q12-E271) .

Clonality

Polyclonal

Tissue Specificity

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Applications

Flow Cytometry

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

References & Citations

1. Ahuja, J. S., Sandhu, R., Mainpal, R., Lawson, C., Henley, H., Hunt, P. A., Yanowitz, J. L., Borner, G. V. Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome. Science 355: 408-411, 2017. 2. Jantsch, V., Pasierbek, P., Mueller, M. M., Schweizer, D., Jantsch, M., Loidl, J. Targeted gene knockout reveals a role in meiotic recombination for ZHP-3, a Zip3-related protein in Caenorhabditis elegans. Molec. Cell. Biol. 24: 7998-8006, 2004. 3. Kong, A., Thorleifsson, G., Stefansson, H., Masson, G., Helgason, A., Gudbjartsson, D. F., Jonsdottir, G. M., Gudjonsson, S. A., Sverrisson, S., Thorlacius, T., Jonasdottir, A., Hardarson, G. A., Palsson, S. T., Frigge, M. L., Gulcher, J. R., Thorsteinsdottir, U., Stefansson, K. Sequence variants in the RNF212 gene associate with genome-wide recombination rate. Science 319: 1398-1401, 2008.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Eva-1 homolog A, regulator of programmed cell death

Subcellular Location

Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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