Anti-RBMY1A1 Antibody Picoband® Fluoro488 Conjugated

RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the RBMY1A1 gene. This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein is thought to function as a splicing regulator during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins.

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM) . Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

1. Chai, N. N., Salido, E. C., Yen, P. H. Multiple functional copies of the RBM gene family, a spermatogenesis candidate on the human Y chromosome. Genomics 45: 355-361, 1997. 2. Delbridge, M. L., Harry, J. L., Toder, R., Waugh O'Neill, R. J., Ma, K., Chandley, A. C., Marshall Graves, J. A. A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome. Nature Genet. 15: 131-136, 1997. Note: Erratum: Nature Genet. 15: 411 only, 1997. 3. Delbridge, M. L., Lingenfelter, P. A., Disteche, C. M., Marshall Graves, J. A. The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome. (Letter) Nature Genet. 22: 223-224, 1999.