Anti-RHBDF2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Rhomboid family member 2 is a protein that in humans is encoded by the RHBDF2 gene. Predicted to enable protein transporter activity. Predicted to be involved in negative regulation of protein secretion and regulation of epidermal growth factor receptor signaling pathway. Located in plasma membrane. Implicated in palmoplantar keratoderma-esophageal carcinoma syndrome.
Synonyms
Chromaffin granule amine transporter; Solute carrier family 18 member 1; Vesicular amine transporter 1; VAT1; SLC18A1; VAT1; VMAT1
Gene Name
RHBDF2
Gene ID
79651
UniProt
Q6PJF5
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human RHBDF2 recombinant protein (Position: H145-D529) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in chromaffin cells of the adrenal medulla (at protein level) . Detected in peripheral sympathetic ganglia (at protein level) . Found in some paracrine cells in stomach and duodenum (at protein level) .
Applications
Flow Cytometry
Field of Research
Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.
References & Citations
1. Adrain, C., Zettl, M., Cristova, Y., Taylor, N., Freeman, M. Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science 335: 225-228, 2012. 2. Blaydon, D. C., Etheridge, S. L., Risk, J. M., Hennies, H.-C., Gay, L. J., Carroll, R., Plagnol, V., McRonald, F. E., Stevens, H. P., Spurr, N. K., Bishop, D. T., Ellis, A., Jankowski, J., Field, J. K., Leigh, I. M., South, A. P., Kelsell, D. P. RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. Am. J. Hum. Genet. 90: 340-346, 2012. 3. Brooke, M. A., Etheridge, S. L., Kaplan, N., Simpson, C., O'Toole, E. A., Ishida-Yamamoto, A., Marches, O., Getsios, S., Kelsell, D. P. iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function. Hum. Molec. Genet. 23: 4064-4076, 2014.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
49229 MW
Applications Notes
6
Gene Name Synonym
Solute carrier family 18 member A1
Subcellular Location
Cytoplasmic vesicle membrane. Multi-pass membrane protein. Synaptic vesicle membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein.
Protein Name
Chromaffin granule amine transporter
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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