Anti-Pirh2/RCHY1 Antibody Picoband® Fluoro647 Conjugated

RING finger and CHY zinc finger domain-containing protein 1 is a protein that in humans is encoded by the RCHY1 gene. The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Angiogenesis, Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors ly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.

1. Fedorova, O. , Gudovich, A. , Daks, A. , Baidyuk, E. , & Barlev, N. A. . (2021) . Regulation of autophagy flux by e3 ubiquitin ligase pirh2 in lung cancer. Biochemical and Biophysical Research Communications, 563, 119-125. 2. Yifeng, Bao, Xue, Wu, Debin, & Yuan, et al. (2017) . High expression of pirh2 is associated with poor prognosis in glioma. Cellular and molecular neurobiology. 3. Yang, ShuyunChen, YingyingSun, FulanNi, QichaoWang, HuaHuang, YeqingZhang, ChunhuiLiu, KunWang, ShuoQiu, JianXu, ZhenHua, LuHe, Zhixian. (2016) . Downregulated pirh2 can decrease the proliferation of breast cancer cells. Archives of medical research, 47 (3) .