Anti-RBM11 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Putative RNA-binding protein 11 is a protein that in humans is encoded by the RBM11 gene. Enables poly (U) RNA binding activity and protein homodimerization activity. Acts upstream of or within cellular response to oxidative stress and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck.
Synonyms
Alpha-amylase 1;3.2.1.1;1,4-alpha-D-glucan glucanohydrolase 1; Salivary alpha-amylase; AMY1A; AMY1; AMY1B; AMY1; AMY1C; AMY1
Gene Name
RBM11
Gene ID
54033
UniProt
P57052
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human RBM11 recombinant protein (Position: M1-K246) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.
Applications
Flow Cytometry
Field of Research
Complement, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
References & Citations
1. Gross, M. B. Personal Communication. Baltimore, Md. 4/12/2018. 2. Pedrotti, S., Busa, R., Compagnucci, C., Sette, C. The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. Nucleic Acids Res. 40: 1021-1032, 2012.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
57768 MW
Applications Notes
6
Gene Name Synonym
Alpha-amylase 1
Subcellular Location
Secreted.
Protein Name
Alpha-amylase 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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