Anti-Asparagine synthetase/ASNS Antibody Picoband® Fluoro647 Conjugated

The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene.

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

1. Abhyankar, A., Lamendola-Essel, M., Brennan, K., Giordano, J. L., Esteves, C., Felice, V., Wapner, R., Jobanputra, V. Clinical whole exome sequencing from dried blood spot identifies novel genetic defect underlying asparagine synthetase deficiency. Clin. Case Rep. 6: 200-205, 2018. 2. Arfin, S. M., Cirullo, R. E., Arredondo-Vega, F. X., Smith, M. Assignment of the structural gene for asparagine synthetase to human chromosome 7. Somat. Cell Genet. 9: 517-531, 1983. 3. Greco, A., Ittmann, M., Barletta, C., Basilico, C., Croce, C. M., Cannizzaro, L. A., Huebner, K. Chromosomal localization of human genes required for G (1) progression in mammalian cells. Genomics 4: 240-245, 1989.