Anti-RARS/RARS1 Antibody Picoband®

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family.

Widely expressed (PubMed:11097842) . Expressed strongly in colorectal cancer cells (at protein level) (PubMed:28040436) . Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436) . Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436) .

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602) . Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER) -mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292) . Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC) -binding activity (PubMed:25284789) . Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789) .

1. Anderson, L. L., Mao, X., Scott, B. A., Crowder, C. M. Survival from hypoxia in C. elegans by inactivation of aminoacyl-tRNA synthetases. Science 323: 630-633, 2009. 2. Arfin, S., Carlock, L., Gerken, S., Wasmuth, J. Clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5. (Abstract) Am. J. Hum. Genet. 37: A228, 1985. 3. Carlock, L. R., Skarecky, D., Dana, S. L., Wasmuth, J. J. Deletion mapping of human chromosome 5 using chromosome-specific DNA probes. Am. J. Hum. Genet. 37: 839-852, 1985.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.