Anti-TMEM59 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene. This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants.
Synonyms
B-cell differentiation antigen CD72; Lyb-2; CD72; CD72
Gene Name
TMEM59
Gene ID
9528
UniProt
Q9BXS4
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TMEM59 recombinant protein (Position: A37-I323) .
Clonality
Polyclonal
Tissue Specificity
Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays a role in B-cell proliferation and differentiation.
References & Citations
1. Boada-Romero, E., Letek, M., Fleischer, A., Pallauf, K., Ramon-Barros, C., Pimentel-Muinos, F. X. TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3. EMBO J. 32: 566-582, 2013. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 08/19/2016. 3. Ullrich, S., Munch, A., Neumann, S., Kremmer, E., Tatzelt, J., Lichtenthaler, S. F. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J. Biol. Chem. 285: 20664-20674, 2010.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
CD72 molecule
Subcellular Location
Membrane; Single-pass type II membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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