Anti-GCM1 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene. This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif) . The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm) . This protein binds to the GCM-motif (A/G) CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.
Synonyms
Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF; VEGFB; VRF
Gene Name
GCM1
Gene ID
8521
UniProt
Q9NP62
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human GCM1 recombinant protein (Position: E188-R436) .
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
References & Citations
1. Akiyama, Y., Hosoya, T., Poole, A. M., Hotta, Y. The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals. Proc. Nat. Acad. Sci. 93: 14912-14916, 1996. 2. Anson-Cartwright, L., Dawson, K., Holmyard, D., Fisher, S. J., Lazzarini, R. A., Cross, J. C. The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta. Nature Genet. 25: 311-314, 2000. 3. Gunther, T., Chen, Z.-F., Kim, J., Priemel, M., Rueger, J. M., Amling, M., Moseley, J. M., Martin, T. J., Anderson, D. J., Karsenty, G. Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature 406: 199-203, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Vascular endothelial growth factor B
Subcellular Location
Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6179321-01 0.1 mL
NTRK2 (Neurotrophic Tyrosine Kinase, Receptor, Type 2, GP145-TrkB, TRKB) (HRP)
Sign In for Pricing
View Details 
MBS6179321-02 5x 0.1 mL
NTRK2 (Neurotrophic Tyrosine Kinase, Receptor, Type 2, GP145-TrkB, TRKB) (HRP)
Sign In for Pricing
View Details MBS7087571 Inquire
Recombinant Drosophila mauritiana ATP synthase subunit a (mt:ATPase6), partial
Sign In for Pricing
View Details TA803485S 30 µL
Melanoma gp100 (PMEL) Mouse Monoclonal Antibody [Clone ID: OTI3G5]
Sign In for Pricing
View Details 
NBP2-90679G 0.1 mL
Rabbit Monoclonal UCH-L3 Antibody (153) [DyLight 488]
Sign In for Pricing
View Details