Anti-GWL/MASTL Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.
Synonyms
Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1; Xcl1; Lptn; Ltn; Scyc1
Gene Name
MASTL
Gene ID
84930
UniProt
Q96GX5
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human GWL/MASTL recombinant protein (Position: K179-L872) .
Clonality
Polyclonal
Tissue Specificity
Expressed in activated CD8 (+) T cells. In the thymus, expressed by medullary thymic epithelial cells.
Applications
Flow Cytometry
Field of Research
Chemokines, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
References & Citations
1. Di Paola, J., Johnson, J. Thrombocytopenias due to gray platelet syndrome or THC2 mutations. Semin. Thromb. Hemost. 37: 690-697, 2011. 2. Drachman, J. G., Jarvik, G. P., Mehaffey, M. G. Autosomal dominant thrombocytopenia: incomplete megakaryocyte differentiation and linkage to human chromosome 10. Blood 96: 118-125, 2000. 3. Gandhi, M. J., Cummings, C. L., Drachman, J. G. FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. Hum. Hered. 55: 66-70, 2003.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Chemokine (C motif) ligand 1
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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