Anti-Quiescin Q6/QSOX1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Sulfhydryl oxidase 1 is an enzyme that in humans is encoded by the QSOX1 gene. This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.
Synonyms
Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1; Xcl1; Lptn; Ltn; Scyc1
Gene Name
QSOX1
Gene ID
5768
UniProt
O00391
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Quiescin Q6/QSOX1 recombinant protein (Position: R32-Q421) .
Clonality
Polyclonal
Tissue Specificity
Expressed in activated CD8 (+) T cells. In the thymus, expressed by medullary thymic epithelial cells.
Applications
Flow Cytometry
Field of Research
Chemokines, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
References & Citations
1. Alon, A., Grossman, I., Gat, Y., Kodali, V. K., DiMaio, F., Mehlman, T., Haran, G., Baker, D., Thorpe, C., Fass, D. The dynamic disulphide relay of quiescin sulphydryl oxidase. Nature 488: 414-418, 2012. 2. Coppock, D. L., Cina-Poppe, D., Gilleran, S. The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. Genomics 54: 460-468, 1998. 3. Coppock, D. L., Kopman, C., Scandalis, S., Gilleran, S. Preferential gene expression in quiescent human lung fibroblasts. Cell Growth Differ. 4: 483-493, 1993.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Chemokine (C motif) ligand 1
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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