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Anti-RAB3GAP1 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

A04789-2-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Rab3 GTPase-activating protein catalytic subunit is an enzyme that in humans is encoded by the RAB3GAP1 gene. This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.

Synonyms

Ras GTPase-activating-like protein IQGAP2; IQGAP2

Gene Name

RAB3GAP1

Gene ID

22930

UniProt

Q15042

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RAB3GAP1 recombinant protein (Position: N109-Q810) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine.

Applications

Flow Cytometry

Field of Research

Calcium Signaling, Calmodulin Pathway, G Protein Signaling, Ras Family, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

References & Citations

1. Abdel-Hamid, M. S., Abdel-Ghafar, S. F., Ismail, S. R., Desouky, L. M., Issa, M. Y., Effat, L. K., Zaki, M. S. Micro and Martsolf syndromes in 34 new patients: refining the phenotypic spectrum and further molecular insights. Clin. Genet. 98: 445-456, 2020. 2. Abdel-Salam, G. M. H., Hassan, N. A., Kayed, H. F., Aligianis, I. A. Phenotypic variability in Micro syndrome: report of new cases. Genet. Counsel. 18: 423-435, 2007. 3. Aligianis, I. A., Johnson, C. A., Gissen, P., Chen, D., Hampshire, D., Hoffmann, K., Maina, E. N., Morgan, N. V., Tee, L., Morton, J., Ainsworth, J. R., Horn, D., and 20 others. Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome. Nature Genet. 37: 221-223, 2005.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

IQ motif containing GTPase activating protein 2

Subcellular Location

Membrane. Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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