Anti-T12/CD6 Antibody Picoband® Fluoro550 Conjugated

CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene. This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685) . Multiple transcript variants encoding different isoforms have been found for this gene.

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. ly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in ing the differentiation of retinal progenitors towards horizontal and amacrine fates.

1. Aruffo, A., Melnick, M. B., Linsley, P. S., Seed, B. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. J. Exp. Med. 174: 949-952, 1991. 2. Bowen, M. A., Whitney, G. S., Neubauer, M., Starling, G. C., Palmer, D., Zhang, J., Nowak, N. J., Shows, T. B., Aruffo, A. Structure and chromosomal location of the human CD6 gene. J. Immun. 158: 1149-1156, 1997. 3. De Jager, P. L., Jia, X., Wang, J., de Bakker, P. I. W., Ottoboni, L., Aggarwal, N. T., Picco, L., Raychaudhuri, S., Tran, D., Aubin, C., Briskin, R., Romano, S., and 22 others. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nature Genet. 41: 776-782, 2009.