Anti-ARS2/SRRT Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene. Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in primary miRNA processing. Located in nucleoplasm. Part of ribonucleoprotein complex.
Synonyms
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit IV isoform 1; COX IV-1; COX4I1; COX4
Gene Name
SRRT
Gene ID
51593
UniProt
Q9BXP5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ARS2/SRRT recombinant protein (Position: H125-Q793) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitous.
Applications
Flow Cytometry
Field of Research
Cancer, Cancer Metabolism, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolism, Mitochondria, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Organelles, Oxidative Phosphorylation, Pathways and Processes, Signal Transduction, Subcellular Markers, Tags & Cell Markers
Purification
Immunogen affinity purified.
Form
Liquid
Function
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
References & Citations
1. Andreu-Agullo, C., Maurin, T., Thompson, C. B., Lai. E. C. Ars2 maintains neural stem-cell identity through transcriptional activation of Sox2. Nature 481: 195-198, 2011. 2. Gruber, J. J., Zatechka, D. S., Sabin, L. R., Yong, J., Lum, J. J., Kong, M., Zong, W.-X., Zhang, Z., Lau, C.-K., Rawlings, J., Cherry, S., Ihle, J. N., Dreyfuss, G., Thompson, C. B. Ars2 links nuclear cap-binding complex to RNA interference and cell proliferation. Cell 138: 328-339, 2009. 3. Kiriyama, M., Kobayashi, Y., Saito, M., Ishikawa, F., Yonehara, S. Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. Molec. Cell. Biol. 29: 4729-4741, 2009.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
101 kDa
Applications Notes
6
Gene Name Synonym
Cytochrome c oxidase subunit 4I1
Subcellular Location
Mitochondrion inner membrane.
Protein Name
Zinc finger protein Helios
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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