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Anti-STMN3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Stathmin-3 is a protein that in humans is encoded by the STMN3 gene. This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants.

Synonyms

Annexin A8 ; Annexin VIII ; Annexin-8 ; Vascular anticoagulant-beta ; VAC-beta ; ANXA8 ; ANX8

Gene Name

STMN3

Gene ID

50861

UniProt

Q9NZ72

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human STMN3 recombinant protein (Position: F25-H156) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed.

Applications

Flow Cytometry

Field of Research

Signal Transduction, Cardiovascular, Cytoskeleton, Cytoskeleton/ECM, Actin Binding Proteins, Actin, etc., Microfilaments, Cell Adhesion

Purification

Immunogen affinity purified.

Form

Liquid

Function

This protein is an anticoagulant protein that acts as an in inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

References & Citations

1. Bieche, I., Maucuer, A., Laurendeau, I., Lachkar, S., Spano, A. J., Frankfurter, A., Levy, P., Manceau, V., Sobel, A., Vidaud, M., Curmi, P. A. Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP. Genomics 81: 400-410, 2003. 2. Gavet, O., Ozon, S., Manceau, V., Lawler, S., Curmi, P., Sobel, A. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. J. Cell Sci. 111: 3333-3346, 1998. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 12/23/2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

36881 MW

Applications Notes

6

Gene Name Synonym

Annexin A8

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Protein Name

Annexin A8

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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