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Anti-WDR24 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

WD repeat-containing protein 24 is a protein that in humans is encoded by the WDR24 gene. WDR24 is a component ofthe GATOR2 complex which hasfive known subunits (WDR24, WDR59, Mios, Sec13, and Seh1L) . GATOR2 complex positively regulates mTORC1 signaling by acting upstream of orin parallel to GATOR1, which is a GTPase-activating protein (GAP) for RagA or RagB and an inhibitor ofthe amino-acid-sensing pathway.

Synonyms

Mitochondrial import inner membrane translocase subunit Tim17-A; Inner membrane preprotein translocase Tim17a; TIMM17A; MIMT17; TIM17; TIM17A; TIMM17

Gene Name

WDR24

Gene ID

84219

UniProt

Q96S15

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human WDR24 recombinant protein (Position: H309-H762) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cancer, Metabolism, Mitochondrial Metabolism, Organelle Proteins, Pathways and Processes, Protein Trafficking, Signal Transduction, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

References & Citations

1. Robert, A. , Saxton, Kevin, E. , Knockenhauer, Rachel, L. , & Wolfson, et al. (2016) . Structural basis for leucine sensing by the sestrin2-mtorc1 pathway. Science (New York, N.Y.) . 2. Wolfson, R. L. , Chantranupong, L. , Saxton, R. A. , Kuang, S. , Scaria, S. M. , & Cantor, J. R. , et al. (2016) . [Research Article] Sestrin2 is a leucine sensor for the mTORC1 pathway. 3. Wang, D., Xu, C., Yang, W., Chen, J., Ou, Y., Guan, Y., ... & Liu, Y. (2022) . E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. Molecular Cell, 82 (4), 770-784.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Translocase of inner mitochondrial membrane 17A

Subcellular Location

Mitochondrion inner membrane, Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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