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Anti-Spermidine synthase/SRM Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.

Synonyms

Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox; NCF1; NOXO2; SH3PXD1A

Gene Name

SRM

Gene ID

6723

UniProt

P19623

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Spermidine synthase/SRM recombinant protein (Position: A15-E292) .

Clonality

Polyclonal

Tissue Specificity

Detected in peripheral blood monocytes and neutrophils (at protein level) .

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production) .

References & Citations

1. Myohanen, S., Kauppinen, L., Wahlfors, J., Alhonen, L., Janne, J. Human spermidine synthase gene: structure and chromosomal localization. DNA Cell Biol. 10: 467-474, 1991. 2. Wahlfors, J., Alhonen, L., Kauppinen, L., Hyvonen, T., Janne, J., Eloranta, T. O. Human spermidine synthase: cloning and primary structure. DNA Cell Biol. 9: 103-110, 1990. Note: Erratum: DNA Cell Biol. 9: 543 only, 1990. 3. Winqvist, R., Alanen, L., Grzeschik, K.-H., Janne, J., Eloranta, T. Mapping of DNA sequences for spermidine synthase to human chromosome 1p36-p22 and chromosome 3p14-q21. (Abstract) Cytogenet. Cell Genet. 58: 1865 only, 1991.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

34140 MW

Applications Notes

6

Gene Name Synonym

Neutrophil cytosolic factor 1

Subcellular Location

Cytoplasm, cytosol.

Protein Name

Growth/differentiation factor 15

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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