Anti-Spermidine synthase/SRM Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.
Synonyms
Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox; NCF1; NOXO2; SH3PXD1A
Gene Name
SRM
Gene ID
6723
UniProt
P19623
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Spermidine synthase/SRM recombinant protein (Position: A15-E292) .
Clonality
Polyclonal
Tissue Specificity
Detected in peripheral blood monocytes and neutrophils (at protein level) .
Applications
Flow Cytometry
Field of Research
Cancer, Cancer Metabolism, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production) .
References & Citations
1. Myohanen, S., Kauppinen, L., Wahlfors, J., Alhonen, L., Janne, J. Human spermidine synthase gene: structure and chromosomal localization. DNA Cell Biol. 10: 467-474, 1991. 2. Wahlfors, J., Alhonen, L., Kauppinen, L., Hyvonen, T., Janne, J., Eloranta, T. O. Human spermidine synthase: cloning and primary structure. DNA Cell Biol. 9: 103-110, 1990. Note: Erratum: DNA Cell Biol. 9: 543 only, 1990. 3. Winqvist, R., Alanen, L., Grzeschik, K.-H., Janne, J., Eloranta, T. Mapping of DNA sequences for spermidine synthase to human chromosome 1p36-p22 and chromosome 3p14-q21. (Abstract) Cytogenet. Cell Genet. 58: 1865 only, 1991.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
34140 MW
Applications Notes
6
Gene Name Synonym
Neutrophil cytosolic factor 1
Subcellular Location
Cytoplasm, cytosol.
Protein Name
Growth/differentiation factor 15
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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