Anti-Sarcalumenin/Srl Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Sarcalumenin is a protein that in humans is encoded by the SRL gene. Predicted to enable GTP binding activity. Acts upstream of or within response to muscle activity involved in regulation of muscle adaptation and store-operated calcium entry. Predicted to be located in membrane and sarcoplasmic reticulum. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. Is expressed in brain ventricular layer; diaphragm; limb; skeletal musculature; and tail mesenchyme. Orthologous to human SRL (sarcalumenin) .
Synonyms
Chromaffin granule amine transporter; Solute carrier family 18 member 1; Vesicular amine transporter 1; VAT1; SLC18A1; VAT1; VMAT1
Gene Name
Srl
Gene ID
106393
UniProt
Q7TQ48
Host
Rabbit
Reactivity
Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived mouse Sarcalumenin/Srl recombinant protein (Position: R119-M422) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in chromaffin cells of the adrenal medulla (at protein level) . Detected in peripheral sympathetic ganglia (at protein level) . Found in some paracrine cells in stomach and duodenum (at protein level) .
Applications
Flow Cytometry
Field of Research
Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.
References & Citations
1. Leberer, E., Charuk, J. H. M., Clarke, D. M., Green, N. M., Zubrzycka-Gaarn, E., MacLennan, D. H. Molecular cloning and expression of cDNA encoding the 53,000-dalton glycoprotein of rabbit skeletal muscle sarcoplasmic reticulum. J. Biol. Chem. 264: 3484-3493, 1989. 2. Leberer, E., Charuk, J. H. M., Green, N. M., MacLennan, D. H. Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum. Proc. Nat. Acad. Sci. 86: 6047-6051, 1989. 3. Scott, A. Personal Communication. Baltimore, Md. 9/30/1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
49229 MW
Applications Notes
6
Gene Name Synonym
Solute carrier family 18 member A1
Subcellular Location
Cytoplasmic vesicle membrane. Multi-pass membrane protein. Synaptic vesicle membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein.
Protein Name
Chromaffin granule amine transporter
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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