Anti-PCTP-L/STARD10 Antibody Picoband® Fluoro488 Conjugated

StAR-related lipid transfer protein 10 (STARD10) or PCTP-like protein is a lipid transfer protein that in humans is encoded by the STARD10 gene. StarD10 is a dual-specificity lipid transfer protein capable of shuttling phosphatidylcholine (PC) and phosphatidylethanolamine (PE) between membranes in vitro; changes in membrane composition of PC and PE occur before the morphological tumorigenic events. Interestingly, STARD10 has been described to be highly expressed in 35-40% of ERBB2-positive breast cancers. StarD10 was initially discovered based on its cross-reactivity with a phosphoserine-specific antibody in mammary tumors from Neu/ErbB2 transgenic mice and subsequently isolated from SKBR3 human breast carcinoma cells using a multistep biochemical purification strategy. StarD10 contains a steroidogenic acute regulatory protein (StAR/StarD1) -related lipid transfer (START) domain that is thought to mediate binding of lipids. STARD10 is highly expressed in the liver and has been shown to transfer phosphatidylcholine.

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. .

1. Ito, M., Yamanashi, Y., Toyoda, Y., Izumi-Nakaseko, H., Oda, S., Sugiyama, A., Kuroda, M., Suzuki, H., Takada, T., Adachi-Akahane, S. Disruption of Stard10 gene alters the PPAR-alpha-mediated bile acid homeostasis. Biochim. Biophys. Acta 1831: 459-468, 2013. 2. Olayioye, M. A., Buchholz, M., Schmid, S., Schoffler, P., Hoffmann, P., Pomorski, T. Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. J. Biol. Chem. 282: 22492-22498, 2007. 3. Olayioye, M. A., Hoffmann, P., Pomorski, T., Armes, J., Simpson, R. J., Kemp, B. E., Lindeman, G. J., Visvader, J. E. The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation. Cancer Res. 64: 3538-3544, 2004.