Anti-SNX15 Antibody Picoband®

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

1. Guru, S. C., Agarwal, S. K., Manickam, P., Olufemi, S.-E., Crabtree, J. S., Weisemann, J. M., Kester, M. B., Kim, Y. S., Wang, Y., Emmert-Buck, M. R., Liotta, L. A., Spiegel, A. M., Boguski, M. S., Roe, B. A., Collins, F. S., Marx, S. J., Burns, L., Chandrasekharappa, S. C. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. Genome Res. 7: 725-735, 1997. 2. Phillips, S. A., Barr, V. A., Haft, D. H., Taylor, S. I., Haft, C. R. Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking. J. Biol. Chem. 276: 5074-5084, 2001.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.