Anti-Sm-D3/SNRPD3 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene. This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants.
Synonyms
Mediator of RNA polymerase II transcription subunit 20; Mediator complex subunit 20; TRF-proximal protein homolog; hTRFP; MED20; TRFP
Gene Name
SNRPD3
Gene ID
6634
UniProt
P62318
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Sm-D3/SNRPD3 recombinant protein (Position: M1-R112) .
Clonality
Polyclonal
Tissue Specificity
Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Applications
Flow Cytometry
Field of Research
Epigenetics and Nuclear Signaling, Mediator Complex, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
References & Citations
1. Lehmeier, T., Raker, V., Hermann, H., Luhrmann, R. cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a D1-D2 interaction. Proc. Nat. Acad. Sci. 91: 12317-12321, 1994.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
CD72 molecule
Subcellular Location
Nucleus .
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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