Anti-SMC2 Antibody Picoband® Fluoro488 Conjugated

Structural maintenance of chromosomes protein 2 (SMC-2) also known as chromosome-associated protein E (CAP-E) is a protein that in humans is encoded by the SMC2 gene. Predicted to enable ATP binding activity; chromatin binding activity; and single-stranded DNA binding activity. Involved in mitotic chromosome condensation. Located in condensed chromosome; cytoplasm; and nuclear lumen. Part of condensin complex.

Mediator of RNA polymerase II transcription subunit 14; Activator-recruited cofactor 150 kDa component; ARC150; Cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; Mediator complex subunit 14; RGR1 homolog; hRGR1; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170; Transcriptional coactivator CRSP150; Vitamin D3 receptor-interacting protein complex 150 kDa component; DRIP150; MED14; ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 2/11/2014. 2. Schmiesing, J. A., Ball, A. R., Jr., Gregson, H. C., Alderton, J. M., Zhou, S., Yokomori, K. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. Proc. Nat. Acad. Sci. 95: 12906-12911, 1998. 3. Schmiesing, J. A., Gregson, H. C., Zhou, S., Yokomori, K. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. Molec. Cell. Biol. 20: 6996-7006, 2000.