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Anti-SMAP1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Stromal membrane-associated protein 1 is a protein that in humans is encoded by the SMAP1 gene. The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms.

Synonyms

Interleukin-17B; IL-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; Neuronal interleukin-17-related factor; Il17b; Nirf, Zcyto7

Gene Name

SMAP1

Gene ID

60682

UniProt

Q8IYB5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SMAP1 recombinant protein (Position: K126-Q416) .

Clonality

Polyclonal

Tissue Specificity

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. .

References & Citations

1. Kobayashi, N., Kon, S., Henmi, Y., Funaki, T., Satake, M., Tanabe, K. The Arf GTPase-activating protein SMAP1 promotes transferrin receptor endocytosis and interacts with SMAP2. Biochem. Biophys. Res. Commun. 453: 473-479, 2014. 2. Marcos, I., Borrego, S., Rodriguez de Cordoba, S., Galan, J. J., Antinolo, G. Cloning, characterization and chromosome mapping of the human SMAP1 gene. Gene 292: 167-171, 2002. 3. Sato, Y., Hong, H. N., Yanai, N., Obinata, M. Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. J. Biochem. 124: 209-216, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Interleukin 17B

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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