Anti-Mitochondrial dicarboxylate carrier/SLC25A10 Antibody Picoband®

The mitochondrial dicarboxylate carrier (DIC) is an integral membrane protein encoded by the SLC25A10 gene in humans that catalyzes the transport of dicarboxylates such as malonate, malate, and succinate across the inner mitochondrial membrane in exchange for phosphate, sulfate, and thiosulfate by a simultaneous antiport mechanism, thus supplying substrates for the Krebs cycle, gluconeogenesis, urea synthesis, fatty acid synthesis, and sulfur metabolism. This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

1. Fiermonte, G., Dolce, V., Arrigoni, R., Runswick, M. J., Walker, J. E., Palmieri, F. Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. Biochem. J. 344: 953-960, 1999. 2. Mizuarai, S., Miki, S., Araki, H., Takahashi, K., Kotani, H. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. J. Biol. Chem. 280: 32434-32441, 2005. 3. Pannone, E., Fiermonte, G., Dolce, V., Rocchi, M., Palmieri, F. Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3. Cytogenet. Cell Genet. 83: 238-239, 1998.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.