Anti-CAT2/SLC7A2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Cationic amino acid transporter 2 is a protein that in humans is encoded by the SLC7A2 gene. The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms
Ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme 25; USP on chromosome 21; Ubiquitin thioesterase 25; Ubiquitin-specific-processing protease 25; USP25; USP21
Gene Name
SLC7A2
Gene ID
89858
UniProt
P52569
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human CAT2/SLC7A2 recombinant protein (Position: M1-F658) .
Clonality
Polyclonal
Tissue Specificity
Isoform USP25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen. Isoform USP25b is found in all tissues except heart and skeletal muscle. Isoform USP25m is heart and skeletal muscle specific.
Applications
Flow Cytometry
Field of Research
Adapters, Coat Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport
Purification
Immunogen affinity purified.
Form
Liquid
Function
Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
References & Citations
1. Closs, E. I., Graf, P., Habermeier, A., Cunningham, J. M., Forstermann, U. Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties. Biochemistry 36: 6462-6468, 1997. 2. Closs, E. CATs, a family of three distinct cationic amino acid transporters. Amino Acids 11: 193-208, 1996. 3. Hoshide, R., Ikeda, Y., Karashima, S., Matsuura, T., Komaki, S., Kishino, T., Niikawa, N., Endo, F., Matsuda, I. Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2) . Genomics 38: 174-178, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A06193-1-Fluoro647
Calculated Molecular Weight
49655 MW
Applications Notes
6
Gene Name Synonym
Ubiquitin specific peptidase 25
Subcellular Location
Cytoplasm. Nucleus. Cytoplasm.
Protein Name
AP-2 complex subunit mu
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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