Anti-IRBIT/AHCYL1 Antibody Picoband® (monoclonal, 2E7D9) Fluoro594 Conjugated
Product Specifications
Background
Putative adenosylhomocysteinase 2 is an enzyme that in humans is encoded by the AHCYL1 gene. The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene.
Synonyms
T-complex protein 1 subunit gamma; TCP-1-gamma; CCT-gamma; hTRiC5; CCT3; CCTG; TRIC5
Gene Name
AHCYL1
Gene ID
10768
UniProt
O43865
Host
Mouse
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human IRBIT/AHCYL1 recombinant protein (Position: E14-K57) .
Clonality
Monoclonal
Clone
Clone: 2E7D9
Tissue Specificity
Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
Applications
Flow Cytometry
Field of Research
Chaperones, Protein Trafficking, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
References & Citations
1. Ando, H., Mizutani, A., Kiefer, H., Tsuzurugi, D., Michikawa, T., Mikoshiba, K. IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Molec. Cell 22: 795-806, 2006. 2. Ando, H., Mizutani, A., Matsu-ura, T., Mikoshiba, K. IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. J. Biol. Chem. 278: 10602-10612, 2003. 3. Ando, H., Mizutani, A., Mikoshiba, K. An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage. J. Neurochem. 109: 539-550, 2009.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Chaperonin containing TCP1 subunit 3
Subcellular Location
Cytoplasm.
Isotype
IgG1
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7192304 Inquire
Rabbit anti-Drosophila melanogaster (Fruit fly) Dp Polyclonal Antibody
Sign In for Pricing
View Details