Anti-SLC40A1 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene, and is part of the Ferroportin (Fpn) Family.
Synonyms
Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5; IGFBP5; IBP5
Gene Name
SLC40A1
Gene ID
30061
UniProt
Q9NP59
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SLC40A1 recombinant protein (Position: M1-V571) .
Clonality
Polyclonal
Tissue Specificity
Osteosarcoma, and at lower levels in liver, kidney and brain.
Applications
Flow Cytometry
Field of Research
Growth Factors/Hormones, Lipid Signaling, Signal Transduction, Signaling Pathway
Purification
Immunogen affinity purified.
Form
Liquid
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
References & Citations
1. Agarwal, S., Sankar, V. H., Tewari, D., Pradhan, M. Ferroportin (SLC40A1) gene in thalassemic patients of Indian descent. (Letter) Clin. Genet. 70: 86-87, 2006. 2. Cazzola, M., Cremonesi, L., Papaioannou, M., Soriani, N., Kioumi, A., Charalambidou, A., Paroni, R., Romtsou, K., Levi, S., Ferrari, M., Arosio, P., Christakis, J. Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3) . Brit. J. Haemat. 119: 539-546, 2002. 3. Cremonesi, L., Forni, G. L., Soriani, N., Lamagna, M., Fermo, I., Daraio, F., Galli, A., Pietra, D., Malcovati, L., Ferrari, M., Camaschella, C., Cazzola, M. Genetic and clinical heterogeneity of ferroportin disease. Brit. J. Haemat. 131: 663-670, 2005. Note: Erratum: Brit. J. Haemat. 132: 806 only, 2006.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
30570 MW
Applications Notes
6
Gene Name Synonym
Insulin-like growth factor-binding protein 5
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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