Anti-OAT3/SLC22A8 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Solute carrier family 22 member 8, or organic anion transporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene. This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Synonyms
Muscarinic acetylcholine receptor M1; CHRM1
Gene Name
SLC22A8
Gene ID
9376
UniProt
Q8TCC7
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human OAT3/SLC22A8 recombinant protein (Position: M1-Q470) .
Clonality
Polyclonal
Tissue Specificity
Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level) . Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Applications
Flow Cytometry
Field of Research
Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
References & Citations
1. Race, J. E., Grassl, S. M., Williams, W. J., Holtzman, E. J. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3) . Biochem. Biophys. Res. Commun. 255: 508-514, 1999. 2. Sun, W., Wu, R. R., van Poelje, P. D., Erion, M. D. Isolation of a family of organic anion transporters from human liver and kidney. Biochem. Biophys. Res. Commun. 283: 417-422, 2001.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
211344 MW
Applications Notes
6
Gene Name Synonym
Cholinergic receptor muscarinic 1
Subcellular Location
Cell membrane. Multi-pass membrane protein. Postsynaptic cell membrane. Multi-pass membrane protein.
Protein Name
Chromodomain-helicase-DNA-binding protein 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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