Anti-SLC17A5 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Sialin, also known as H (+) /nitrate cotransporter and H (+) /sialic acid cotransporter, is a protein which in humans is encoded by the SLC17A5 gene. This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form.
Synonyms
Ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinating enzyme 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21; USP21; USP23; PP1490
Gene Name
SLC17A5
Gene ID
26503
UniProt
Q9NRA2
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SLC17A5 recombinant protein (Position: M1-R365) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
Applications
Flow Cytometry
Field of Research
Cofactors, Vitamins/Minerals, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals
Purification
Immunogen affinity purified.
Form
Liquid
Function
Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.
References & Citations
1. Aula, N., Salomaki, P., Timonen, R., Verheijen, F., Mancini, G., Mansson, J.-E., Aula, P., Peltonen, L. The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation. Am. J. Hum. Genet. 67: 832-840, 2000. 2. Berra, B., Gornati, R., Rapelli, S., Gatti, R., Mancini, G. M. S., Ciana, G., Bembi, B. Infantile sialic acid storage disease: biochemical studies. Am. J. Med. Genet. 58: 24-31, 1995. 3. Biancheri, R., Rossi, A., Verbeek, H. A., Schot, R., Corsolini, F., Assereto, S., Mancini, G. M. S., Verheijen, F. W., Minetti, C., Filocamo, M. Homozygosity for the p.K136E mutation in the SLC17A5 gene as cause of an Italian severe Salla disease. Neurogenetics 6: 195-199, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
104553 MW
Applications Notes
6
Gene Name Synonym
Ubiquitin specific peptidase 21
Subcellular Location
Nucleus. Cytoplasm.
Protein Name
AP-2 complex subunit beta
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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