Anti-SLC17A5 Antibody Picoband® Fluoro550 Conjugated

Sialin, also known as H (+) /nitrate cotransporter and H (+) /sialic acid cotransporter, is a protein which in humans is encoded by the SLC17A5 gene. This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form.

Ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinating enzyme 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21; USP21; USP23; PP1490

Cofactors, Vitamins/Minerals, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.

1. Aula, N., Salomaki, P., Timonen, R., Verheijen, F., Mancini, G., Mansson, J.-E., Aula, P., Peltonen, L. The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation. Am. J. Hum. Genet. 67: 832-840, 2000. 2. Berra, B., Gornati, R., Rapelli, S., Gatti, R., Mancini, G. M. S., Ciana, G., Bembi, B. Infantile sialic acid storage disease: biochemical studies. Am. J. Med. Genet. 58: 24-31, 1995. 3. Biancheri, R., Rossi, A., Verbeek, H. A., Schot, R., Corsolini, F., Assereto, S., Mancini, G. M. S., Verheijen, F. W., Minetti, C., Filocamo, M. Homozygosity for the p.K136E mutation in the SLC17A5 gene as cause of an Italian severe Salla disease. Neurogenetics 6: 195-199, 2005.