Anti-SLC6A17 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
The protein encoded by this gene is a member of the SLC6 family of transporters, which are responsible for the presynaptic uptake of most neurotransmitters. The encoded vesicular transporter is selective for proline, glycine, leucine and alanine. In mouse, the strongest expression of this gene was in cortical and hippocampal tissues where expression increased during embryonic brain development and peaked postnatally. Defects in this gene cause a form of autosomal recessive intellectual disability.
Synonyms
Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/I; Histone H3/j; Histone H3/k; Histone H3/l; HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; H3FJ
Gene Name
SLC6A17
Gene ID
388662
UniProt
Q9H1V8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SLC6A17 recombinant protein (Position: M1-Y694) .
Clonality
Polyclonal
Tissue Specificity
Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Applications
Flow Cytometry
Field of Research
DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling, RNA Processing
Purification
Immunogen affinity purified.
Form
Liquid
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
References & Citations
1. Hoglund, P. J., Adzic, D., Scicluna, S. J., Lindblom, J., Fredriksson, R. The repertoire of solute carriers of family 6: identification of new human and rodent genes. Biochem. Biophys. Res. Commun. 336: 175-189, 2005. 2. Iqbal, Z., Willemsen, M. H., Papon, M.-A., Musante, L., Benevento, M., Hu, H., Venselaar, H., Wissink-Lindhout, W. M., Vulto-van Silfhout, A. T., Vissers, L. E. L. M., de Brouwer, A. P. M., Marouillat, S., Wienker, T. F., Ropers, H. H., Kahrizi, K., Nadif Kasri, N., Najmabadi, H., Laumonnier, F., Kleefstra, T., van Bokhoven, H. Homozygous SLC6A17 mutations cause autosomal-recessive intellectual disability with progressive tremor, speech impairment, and behavioral problems. Am. J. Hum. Genet. 96: 386-396, 2015.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Histone cluster 1 H3 family member a/b/c/d/e/f/g/h/i/j
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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