Anti-SHROOM2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Shroom family member 2 is a protein that in humans is encoded by the SHROOM2 gene. This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene.
Synonyms
Epigen; Epithelial mitogen; EPG; Epgn
Gene Name
SHROOM2
Gene ID
357
UniProt
Q13796
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SHROOM2 recombinant protein (Position: R427-H1138) .
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cancer, Growth Factors, Growth Factors/Hormones, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.
References & Citations
1. Dietz, M. L., Bernaciak, T. M., Vendetti, F., Kielec, J. M., Hildebrand, J. D. Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. J. Biol. Chem. 281: 20542-20554, 2006. 2. Dinulos, M. B., Bassi, M. T., Rugarli, E. I., Chapman, V., Ballabio, A., Disteche, C. M. A new region of conservation is defined between human and mouse X chromosomes. Genomics 35: 244-247, 1996. 3. Schiaffino, M. V., Bassi, M. T., Rugarli, E. I., Renieri, A., Galli, L., Ballabio, A. Cloning of a human homologue of the Xenopus laevis APX gene from the ocular albinism type 1 critical region. Hum. Molec. Genet. 4: 373-382, 1995.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
16799 MW
Applications Notes
6
Gene Name Synonym
Epigen
Subcellular Location
Membrane ; Single-pass type I membrane protein .
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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