Anti-SGT2/SGTB Antibody Picoband®

Predicted to enable molecular adaptor activity. Predicted to be involved in positive regulation of chaperone-mediated protein folding; posttranslational protein targeting to endoplasmic reticulum membrane; and ubiquitin-dependent ERAD pathway. Predicted to be part of TRC complex. Predicted to be active in membrane.

Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Qi, Tian, He-Fen, Sun, Wen-Jing, & Wang, et al. (2019) . Mirrna-365b promotes hepatocellular carcinoma cell migration and invasion by downregulating sgtb. Future oncology (London, England) . 2. Cao, M. , Xu, W. , Yu, J. , Zheng, H. , Tan, X. , & Li, L. , et al. (2013) . Up-regulation of sgtb is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide. Journal of Molecular Histology, 44 (5), 507-518. 3. Heavner, G. A. , Audhya, T. , & Goldstein, G. . (1990) . Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human t cell lines. Regulatory Peptides, 27 (2), 257-262.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.