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Anti-SFXN3 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

SFXN3, a mitochondrial membrane protein, is a member of sideroflexin family. Serum anti-SFXN3 autoantibody was elevated in early stage of the oral squamous cell carcinoma significantly, indicating its clinical value for diagnosis of oral squamous cell carcinoma.

Synonyms

DAP3-binding cell death enhancer 1; Death ligand signal enhancer; DELE1; DELE; KIAA0141

Gene Name

SFXN3

Gene ID

81855

UniProt

Q9BWM7

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SFXN3 recombinant protein (Position: D32-L321) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

Flow Cytometry

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

References & Citations

1. Fleming, M. D., Campagna, D. R., Haslett, J. N., Trenor, C. C., III, Andrews, N. C. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev. 15: 652-657, 2001. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 12/17/2013. 3. Kory, N., Wyant, G. A., Prakash, G., iut de Bos, J., Bottanelli, F., Pacold, M. E., Chan, S. H., Lewis, C. A., Wang, T., Keys, H. R., Guo, Y. E., Sabatini, D. M. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science 362: eaat9528, 2018. Note: Electronic Article.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

64099 MW

Applications Notes

6

Gene Name Synonym

DAP3 binding cell death enhancer 1

Subcellular Location

Mitochondrion.

Protein Name

DAP3 binding cell death enhancer 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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