Anti-SETD3 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
SET domain containing 3 (SETD3) is a protein that in humans is encoded by the SETD3 gene. SETD3 is a histone methyltransferase. In mouse muscle cells, Setd3 catalyzes mono- and dimethylation of histone H3 lysine-4 and H3K36 and promotes transcription of genes required for muscle cell differentiation.
Synonyms
Interleukin-17B; IL-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; Neuronal interleukin-17-related factor; Il17b; Nirf, Zcyto7
Gene Name
SETD3
Gene ID
84193
UniProt
Q86TU7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SETD3 recombinant protein (Position: Q173-R468) .
Clonality
Polyclonal
Tissue Specificity
Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
Applications
Flow Cytometry
Field of Research
Cytokines, Immunology, Innate Immunity, Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. .
References & Citations
1. Eom, G. H., Kim, K.-B., Kim, J. H., Kim, J.-Y., Kim, J.-R., Kee, H. J., Kim, D.-W., Choe, N., Park, H.-J., Son, H.-J., Choi, S.-Y., Kook, H., Seo, S.-B. Histone methyltransferase SETD3 regulates muscle differentiation. J. Biol. Chem. 286: 34733-34742, 2011. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 2/27/2014. 3. Wilkinson, A. W., Diep, J., Dai, S., Liu, S., Ooi, Y. S., Song, D., Li, T.-M., Horton, J. R., Zhang, X., Liu, C., Trivedi, D. V., Ruppel, K. M., and 10 others. SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature 565: 372-376, 2019.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Interleukin 17B
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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