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Anti-SETD3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

SET domain containing 3 (SETD3) is a protein that in humans is encoded by the SETD3 gene. SETD3 is a histone methyltransferase. In mouse muscle cells, Setd3 catalyzes mono- and dimethylation of histone H3 lysine-4 and H3K36 and promotes transcription of genes required for muscle cell differentiation.

Synonyms

Interleukin-17B; IL-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; Neuronal interleukin-17-related factor; Il17b; Nirf, Zcyto7

Gene Name

SETD3

Gene ID

84193

UniProt

Q86TU7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SETD3 recombinant protein (Position: Q173-R468) .

Clonality

Polyclonal

Tissue Specificity

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. .

References & Citations

1. Eom, G. H., Kim, K.-B., Kim, J. H., Kim, J.-Y., Kim, J.-R., Kee, H. J., Kim, D.-W., Choe, N., Park, H.-J., Son, H.-J., Choi, S.-Y., Kook, H., Seo, S.-B. Histone methyltransferase SETD3 regulates muscle differentiation. J. Biol. Chem. 286: 34733-34742, 2011. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 2/27/2014. 3. Wilkinson, A. W., Diep, J., Dai, S., Liu, S., Ooi, Y. S., Song, D., Li, T.-M., Horton, J. R., Zhang, X., Liu, C., Trivedi, D. V., Ruppel, K. M., and 10 others. SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature 565: 372-376, 2019.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Interleukin 17B

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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