Anti-ZPI/SERPINA10 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.
Synonyms
Phosphopantothenate--cysteine ligase, Phosphopantothenoylcysteine synthetase, PPC synthetase, PPCS, COAB
Gene Name
SERPINA10
Gene ID
51156
UniProt
Q9UK55
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ZPI/SERPINA10 recombinant protein (Position: L128-E427) .
Clonality
Polyclonal
Tissue Specificity
Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level) .
Applications
Flow Cytometry
Field of Research
Amino Acid Metabolism, Amino Acids, Cofactors, Vitamins/Minerals, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals
Purification
Immunogen affinity purified.
Form
Liquid
Function
Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine.
References & Citations
1. Han, X., Fiehler, R., Broze, G. J., Jr. Isolation of protein Z-dependent plasma protease inhibitor. Proc. Nat. Acad. Sci. 95: 9250-9255, 1998. 2. Han, X., Huang, Z. F., Fiehler, R., Broze, G. J., Jr. The protein Z-dependent protease inhibitor is a serpin. Biochemistry 38: 11073-11078, 1999. 3. New, L., Liu, K., Kamali, V., Plowman, G., Naughton, B. A., Purchio, A. F. cDNA cloning of rasp-1, a novel gene encoding a plasma protein associated with liver regeneration. Biochem. Biophys. Res. Commun. 223: 404-412, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
48608 MW
Applications Notes
6
Gene Name Synonym
Phosphopantothenoylcysteine synthetase
Subcellular Location
Cytosol.
Protein Name
Serine protease HTRA3
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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