Anti-SERINC5 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Serine incorporator 5 is a protein that in humans is encoded by the SERINC5 gene. Predicted to enable L-serine transmembrane transporter activity. Involved in defense response to virus; detection of virus; and innate immune response. Located in several cellular components, including centrosome; cytosol; and plasma membrane
Synonyms
Inorganic pyrophosphatase 2, mitochondrial; Pyrophosphatase SID6-306; Pyrophosphate phospho-hydrolase 2; PPase 2; PPA2; HSPC124
Gene Name
SERINC5
Gene ID
256987
UniProt
Q86VE9
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SERINC5 recombinant protein (Position: E64-H394) .
Clonality
Polyclonal
Tissue Specificity
Detected in brain, gastric carcinoma, lung, ovary, skeletal muscle, umbilical cord blood and a cell line derived from kidney proximal tubule epithelium.
Applications
Flow Cytometry
Field of Research
Cofactors, Vitamins/Minerals, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals
Purification
Immunogen affinity purified.
Form
Liquid
Function
Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function.
References & Citations
1. Gross, M. B. Personal Communication. Baltimore, Md. 3/23/2012. 2. Inuzuka, M., Hayakawa, M., Ingi, T. Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. J. Biol. Chem. 280: 35776-35783, 2005. 3. Rosa, A., Chande, A., Ziglio, S., De Sanctis, V., Bertorelli, R., Goh, S. L., McCauley, S. M., Nowosielska, A., Antonarakis, S. E., Luban, J., Santoni, F. A., Pizzato, M. HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. Nature 526: 212-217, 2015.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
104553 MW
Applications Notes
6
Gene Name Synonym
Pyrophosphatase (inorganic) 2
Subcellular Location
Mitochondrion.
Protein Name
AP-2 complex subunit beta
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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