Anti-Semaphorin 7a/SEMA7A Antibody Picoband® Fluoro647 Conjugated

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene. This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI) -anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD) . Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

AF4/FMR2 family member 4; ALL1-fused gene from chromosome 5q31 protein; Protein AF-5q31; Major CDK9 elongation factor-associated protein; AFF4; AF5Q31, MCEF; HSPC092

Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. .

1. Czopik, A. K., Bynoe, M. S., Palm, N., Raine, C. S., Medzhitov, R. Semaphorin 7A is a negative regulator of T cell responses. Immunity 24: 591-600, 2006. 2. Gross, M. B. Personal Communication. Baltimore, Md. 9/13/2017. 3. Koh, J.-M., Oh, B., Lee, J. Y., Lee, J.-K., Kimm, K., Kim, G. S., Park, B. L., Cheong, H. S., Shin, H. D., Hong, J. M., Kim, T.-H., Park, E. K., Kim, S.-Y. Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women. J. Hum. Genet. 51: 112-117, 2006.