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Anti-SEC24A Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

SEC24 family, member A (S. cerevisiae) is a protein that in humans is encoded by the SEC24A gene. The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII) -coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms

Cationic amino acid transporter 3; CAT-3; CAT3; Cationic amino acid transporter y+; Solute carrier family 7 member 3; SLC7A3; ATRC3, CAT3

Gene Name

SEC24A

Gene ID

10802

UniProt

O95486

Host

Rabbit

Reactivity

Human, Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SEC24A recombinant protein (Position: Q43-Q1045) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala. .

Applications

Flow Cytometry

Field of Research

Amino Acid Metabolism, Amino Acids, Cancer, Channels, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. .

References & Citations

1. Pagano, A., Letourneur, F., Garcia-Estefania, D., Carpentier, J.-L., Orci, L., Paccaud, J.-P. Sec24 proteins and sorting at the endoplasmic reticulum. J. Biol. Chem. 274: 7833-7844, 1999. 2. Tang, B. L., Kausalya, J., Low, D. Y. H., Lock, M. L., Hong, W. A family of mammalian proteins homologous to yeast Sec24p. Biochem. Biophys. Res. Commun. 258: 679-684, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

67169 MW

Applications Notes

6

Gene Name Synonym

Cationic amino acid transporter 3

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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