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Anti-TTLL2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to be active in cilium.

Synonyms

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

Gene Name

TTLL2

Gene ID

83887

UniProt

Q9BWV7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TTLL2 recombinant protein (Position: A24-E582) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

Flow Cytometry

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

References & Citations

1. Ribeiro, M. , Angelini, L. , Roblesribeiro, P. G. , Stelmach, R. , Santos, U. D. P. , & Terrafilho, M. . (2000) . Characterization of the human tubulin tyrosine ligase-like 1 gene (ttll1) mapping to 22q13.1. Gene, 257 (1), 109-117. 2. Faust, T. B. , Yang, L. , Bacon, C. W. , Jang, G. M. , & Frankel, A. D. . (2018) . The hiv-1 tat protein recruits a ubiquitin ligase to reorganize the 7sk snrnp for transcriptional activation. Elife, 7. 3. Ota, T. , Suzuki, Y. , Nishikawa, T. , Otsuki, T. , Sugiyama, T. , & Irie, R. , et al. (2004) . Complete sequencing and characterization of 21,243 full-length human cdnas. Nature Genetics.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

24145 MW

Applications Notes

6

Gene Name Synonym

Kelch repeat and BTB domain containing 2

Subcellular Location

Cul3-RING ubiquitin ligase complex.

Protein Name

Transmembrane protein 240

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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