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Anti-TSPY1/2/3/4 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Testis-specific Y-encoded protein 1/2/3/4 is a protein that in humans is encoded by the TSPY1/2/3/4 gene. The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of this gene are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse. Alternative splicing results in multiple transcript variants.

Synonyms

Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1; TACC1; KIAA1103

Gene Name

TSPY1/2/3/4

Gene ID

7258/64591/728137/728395

UniProt

Q01534/A6NKD2/P0CV98/P0CV99

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TSPY1/2/3/4 recombinant protein (Position: R16-R247) .

Clonality

Polyclonal

Tissue Specificity

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. .

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Differentiation, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

References & Citations

1. Arnemann, J., Epplen, J. T., Cooke, H. J., Sauermann, U., Engel, W., Schmidtke, J. A human Y-chromosomal DNA sequence expressed in testicular tissue. Nucleic Acids Res. 15: 8713-8724, 1987. 2. Arnemann, J., Jakubiczka, S., Thuring, S., Schmidtke, J. Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY. Genomics 11: 108-114, 1991. 3. Guttenbach, M., Muller, U., Schmid, M. A human moderately repeated Y-specific DNA sequence is evolutionarily conserved in the Y chromosome of the great apes. Genomics 13: 363-367, 1992.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

87794 MW

Applications Notes

6

Gene Name Synonym

Transforming acidic coiled-coil-containing protein 1

Subcellular Location

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. .

Protein Name

Transforming acidic coiled-coil-containing protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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