What sizes are available for Anti-TSHZ1 Antibody Picoband® Fluoro647 Conjugated?

Anti-TSHZ1 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.

Anti-TSHZ1 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-TSHZ1 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-TSHZ1 Antibody Picoband® Fluoro647 Conjugated is A08315-1-Fluoro647.

Q: Is Anti-TSHZ1 Antibody Picoband® Fluoro647 Conjugated in stock?

Anti-TSHZ1 Antibody Picoband® Fluoro647 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

Selected Variant

A08315-1-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Teashirt zinc finger homeobox 1 is a protein that in humans is encoded by the TSHZ1 gene. This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome.

Synonyms

Histone-lysine N-methyltransferase SETDB2; Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2; SETDB2; C13orf4; CLLD8; KMT1F

Gene Name

TSHZ1

Gene ID

10194

UniProt

Q6ZSZ6

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TSHZ1 recombinant protein (Position: K97-R800) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in reproductive organs, such as testis, ovary and prostate.

Applications

Flow Cytometry

Field of Research

Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) . H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

References & Citations

1. Core, N., Caubit, X., Metchat, A., Boned, A., Djabali, M., Fasano, L. Tshz1 is required for axial skeleton, soft palate and middle ear development in mice. Dev. Biol. 308: 407-420, 2007. 2. Feenstra, I., Vissers, L. E. L. M., Pennings, R. J. E., Nillessen, W., Pfundt, R., Kunst, H. P., Admiraal, R. J., Veltman, J. A., van Ravenswaaij-Arts, C. M. A., Brunner, H. G., Cremers, C. W. R. J. Disruption of teashirt zinc finger homeobox 1 is associated with congenital aural atresia in humans. Am. J. Hum. Genet. 89: 813-819, 2011. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 1/12/2012.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

Gene Name Synonym

SET domain bifurcated histone lysine methyltransferase 2

Subcellular Location

Nucleus. Chromosome.

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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